Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10082773 | 0.98 | LMNA (0.47) | LMNAGAAMETAP1TSHROPRM1 | |
| SCHEMBL31599453 | 0.97 | GAA (0.44) | LMNAGAAMETAP1TSHROPRM1 | |
| SCHEMBL14615180 | 0.87 | GAA (0.43) | LMNAGAATSHROPRM1OPRL1 | |
| SCHEMBL13400119 | 0.87 | ACHE (0.48) | GAAOPRM1OPRL1MAPTHRH3 | |
| SCHEMBL14615106 | 0.86 | GAA (0.62) | GAATSHROPRM1OPRL1MAPT | |
| SCHEMBL20651289 | 0.79 | CACNA2D1 (0.41) | GAATSHRMAPTHRH3SIGMAR1 | |
| SCHEMBL10695429 | 0.77 | OPRM1 (0.63) | LMNAMETAP1OPRM1OPRL1KCNH2 | |
| SCHEMBL10695431 | 0.77 | OPRM1 (0.63) | LMNAMETAP1OPRM1OPRL1KCNH2 | |
| SCHEMBL9129676 | 0.77 | OPRM1 (0.63) | LMNAMETAP1OPRM1OPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL25378396 | 0.75 | OPRM1 (0.61) | LMNAMETAP1OPRM1OPRL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757584-A1 | Heterocyclic substituted amides, their production and their use | Abbott GmbH & Co. KG (DE) | 2007-02-28 | — | — | EP | disclosed |