Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | CCR6 | P51684 | 1/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 14/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27202488 | 0.82 | DDX3X (0.73) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL4400767 | 0.77 | MAPT (0.63) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL14615293 | 0.77 | MAPT (0.72) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL13679553 | 0.76 | MAPT (0.71) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL13679550 | 0.75 | MAPT (0.70) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL17354449 | 0.74 | THRB (0.68) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL16782299 | 0.74 | MAPT (1.00) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL14615292 | 0.74 | MAPT (0.69) | SMN1; SMN2KMT2AKDM4ERAB9AMEN1 | |
| SCHEMBL13679543 | 0.73 | MAPT (0.79) | SMN1; SMN2KMT2AMEN1NPC1HTT | |
| SCHEMBL14615278 | 0.72 | MAPT (1.00) | SMN1; SMN2KMT2AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |