Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | AGER | Q15109 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460744 | 0.88 | DPP4 (0.48) | OPRM1TMEM97SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1460997 | 0.86 | OPRM1 (0.55) | OPRM1KCNH2AGERMTNR1A | |
| SCHEMBL1460765 | 0.85 | AGER (0.43) | OPRM1TMEM97AGERMTNR1A | |
| SCHEMBL1461945 | 0.80 | GRIN2B (0.48) | SLC6A2SLC6A4 | |
| SCHEMBL1461003 | 0.78 | SLC6A2 (0.41) | OPRM1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL1460723 | 0.78 | DRD2 (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL19002823 | 0.74 | OPRM1 (0.66) | OPRM1TMEM97SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5355490 | 0.73 | SLC6A2 (0.44) | OPRM1SLC6A2SLC6A4 | |
| SCHEMBL1461010 | 0.73 | ESR2 (0.51) | — | |
| SCHEMBL14409767 | 0.73 | LMNA (0.57) | OPRM1TMEM97LMNAAGERMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4644714-B2 | — | — | 2011-03-02 | — | — | JP | claimed |
| JP-2008524280-A | — | — | 2008-07-10 | — | — | JP | claimed |
| EP-1831158-A1 | NOVEL CYCLOHEXANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-09-12 | — | — | EP | claimed |
| US-7253282-B2 | Hexafluoroisopropanol substituted cyclohexane derivatives | HOFFMAN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | claimed |
| WO-2006066779-A1 | NOVEL CYCLOHEXANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | claimed |
| US-20060135601-A1 | Novel hexafluoroisopropanol substituted cyclohexane derivatives | HOFFMANN-LA ROCHE INC. | 2006-06-22 | — | — | US | claimed |
| EP-1831158-A1 | NOVEL CYCLOHEXANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| US-7253282-B2 | Hexafluoroisopropanol substituted cyclohexane derivatives | HOFFMAN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| WO-2006066779-A1 | NOVEL CYCLOHEXANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135601-A1 | Novel hexafluoroisopropanol substituted cyclohexane derivatives | HOFFMANN-LA ROCHE INC. | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135601-A1 | Novel hexafluoroisopropanol substituted cyclohexane derivatives | NR1H3, NR1H2, NR1I2 | OPRM1 216/4885TMEM97 131/4885SLC6A2 3185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.