Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | PANK1 | Q8TE04 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638692 | 0.87 | ALOX15 (0.42) | LMNAKDM4EACHEAPPTRPA1 | |
| SCHEMBL1638885 | 0.80 | MEN1 (0.47) | MAPTMAPK1MAOB | |
| SCHEMBL27714795 | 0.75 | CYP3A4 (0.39) | KDM4EACHEMAPTMAOBSMN1; SMN2 | |
| SCHEMBL12726300 | 0.70 | CCR1 (0.58) | — | |
| SCHEMBL14620979 | 0.69 | ALDH1A1 (0.46) | LMNATP53SMN1; SMN2PANK1PANK3 | |
| SCHEMBL1637819 | 0.69 | ALOX15 (0.42) | KDM4EACHEAPPTP53 | |
| SCHEMBL22873289 | 0.68 | PARP1 (0.44) | LMNAKDM4E | |
| SCHEMBL13663041 | 0.68 | LMNA (0.50) | LMNAKDM4EMAPTMAPK1TDO2 | |
| SCHEMBL14620919 | 0.68 | ELANE (0.54) | LMNA | |
| SCHEMBL12726405 | 0.68 | MAOB (0.39) | ACHEAPPMAOBSMN1; SMN2PANK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002293-A2 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-01-04 | — | — | WO | disclosed |