Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783958 | 0.75 | TAAR1 (0.41) | TAAR1PNMTCYP2C9ALDH1A1MCL1 | |
| SCHEMBL10955474 | 0.75 | MTNR1A (0.43) | TAAR1PNMTMEN1KMT2AALDH1A1 | |
| SCHEMBL1462095 | 0.74 | CA2 (0.37) | RECQLCA2CA1CA9PTGES2 | |
| SCHEMBL4767876 | 0.74 | TAAR1 (0.58) | TAAR1RECQLPNMTCA1PTGES2 | |
| SCHEMBL23077766 | 0.73 | MEN1 (0.46) | MEN1KMT2AMAPT | |
| SCHEMBL15924708 | 0.72 | TAAR1 (0.53) | TAAR1CA2MGLLCA12CA1 | |
| SCHEMBL25437680 | 0.72 | MGLL (0.62) | TAAR1CA2MGLLCA12CA1 | |
| SCHEMBL6377845 | 0.71 | CA2 (0.54) | CA2CA12CA1CYP2C9CA4 | |
| SCHEMBL3786513 | 0.71 | TAAR1 (0.44) | TAAR1PNMTCYP2C9ALDH1A1 | |
| SCHEMBL28171800 | 0.71 | TAAR1 (0.44) | TAAR1PNMTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493865-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011025938-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |