Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215818 | 0.84 | CA2 (0.39) | CA2RECQLCA1 | |
| SCHEMBL1462274 | 0.74 | TAAR1 (0.37) | CA2RECQLCA1CA9PTGES2 | |
| SCHEMBL1492045 | 0.68 | RECQL (0.40) | CA2RECQLCA1CA9PTGES2 | |
| SCHEMBL1494448 | 0.65 | MGLL (0.37) | CA2RECQLCA1CA9PTGES2 | |
| SCHEMBL2777071 | 0.64 | TNF (0.38) | CA2CA1CA9 | |
| SCHEMBL1462138 | 0.63 | BRAF (0.46) | PTGES2 | |
| SCHEMBL25437680 | 0.62 | MGLL (0.62) | CA2CA1CA9 | |
| SCHEMBL15924708 | 0.62 | TAAR1 (0.53) | CA2CA1CA9 | |
| SCHEMBL14784534 | 0.62 | MAPK1 (0.43) | CA2CA1CA9 | |
| SCHEMBL3238785 | 0.61 | PSEN1 (0.42) | CA2CA1CA9PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493865-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011025938-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |