Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 2/20 | 0.37 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA3 | P07451 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL1463346 | 1.00 | TDP1 (0.78) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| Acrylic Acid SCHEMBL3406953 | 0.91 | TDP1 (0.81) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL31126649 | 0.88 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL452529 | 0.88 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL25711 | 0.88 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| Acrylic Acid SCHEMBL28117148 | 0.87 | TDP1 (0.75) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL331672 | 0.86 | TDP1 (0.95) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2121269 | 0.86 | TDP1 (0.95) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2198423 | 0.86 | TDP1 (0.95) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17476625 | 0.86 | TDP1 (0.95) | TDP1TSHRSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480666-B1 | COMPOSITIONS, METHODS, AND KITS FOR ISOLATING AND ANALYZING NUCLEIC ACIDS USING AN ANION EXCHANGE MATERIAL | QIAGEN GAITHERSBURG INC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9238809-B2 | Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material | QIAGEN GAITHERSBURG, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| EP-2480666-A1 | COMPOSITIONS, METHODS, AND KITS FOR ISOLATING AND ANALYZING NUCLEIC ACIDS USING AN ANION EXCHANGE MATERIAL | QIAGEN Gaithersburg, Inc. (US) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011037692-A1 | COMPOSITIONS, METHODS, AND KITS FOR ISOLATING AND ANALYZING NUCLEIC ACIDS USING AN ANION EXCHANGE MATERIAL | QIAGEN GAITHERSBURG INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| US-20110071031-A1 | COMPOSITIONS, METHODS, AND KITS FOR ISOLATING AND ANALYZING NUCLEIC ACIDS USING AN ANION EXCHANGE MATERIAL | QIAGEN GAITHERSBURG INC. (US) | 2011-03-24 | — | — | US | disclosed |