SCHEMBL14634761

SCHEMBL14634761

Cc1c(Cc2ccc(OC(C)C)cc2)c(O[C@@H]2O[C@H](COC(=O)OC[C@H]3O[C@@H](Oc4nn(C(C)C)c(C)c4Cc4ccc(OC(C)C)cc4)[C@H](O)[C@@H](O)[C@@H]3O)[C@@H](O)[C@H](O)[C@H]2O)nn1C(C)C

nearest known ligand 0.95

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.95
SLC5A1 P13866 18/20 0.95

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL877233 1.00 SLC5A2 (0.95) SLC5A2SLC5A1
SCHEMBL14634764 1.00 SLC5A2 (0.95) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL18432846 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL10066609 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL16421581 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL23072082 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL15168697 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL17034638 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL721678 0.98 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin Etabonate SCHEMBL10081649 0.98 SLC5A2 (1.00) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10894787-B2 Modulators of the GPR119 receptor and the treatment of disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2021-01-19 US claimed
EP-3323818-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2018-05-23 EP claimed
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US claimed
US-11813274-B2 Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor HUA MEDICINE (SHANGHAI) LTD. (CN) 2023-11-14 US disclosed
US-20230000816-A1 SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITORS FOR THE MANAGEMENT OF CHRONIC KIDNEY DISEASE, HYPERTENSION, AND HEART FAILURE IN COMPANION ANIMALS INCREVET, INC. 2023-01-05 US disclosed
US-20210340133-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2021-11-04 US disclosed
US-20210330690-A1 TREATING UNTREATED OR TREATMENT-RESISTANT DIABETES WITH GLUCOKINASE ACTIVATOR AND SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITOR HUA MEDICINE (SHANGHAI) LTD. (CN) 2021-10-28 US disclosed
US-10894787-B2 Modulators of the GPR119 receptor and the treatment of disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2021-01-19 US disclosed
US-10463676-B2 Modified-release dosage forms of 5-HT2C agonists useful for weight management ARENA PHARMACEUTICALS, INC. (US) 2019-11-05 US disclosed
WO-2019202149-A1 SGLT2 INHIBITORS FOR THE TREATMENT OF NEUTROPENIA Université Catholique de Louvain (BE) 2019-10-24 WO disclosed
US-20190275055-A1 Modified-Release Dosage Forms of 5-Ht2c Agonists Useful for Weight Management ARENA PHARMACEUTICALS, INC. 2019-09-12 US disclosed
US-9248133-B2 Salts of lorcaserin with optically active acids ARENA PHARMACEUTICALS, INC. (US) 2016-02-02 US disclosed
US-20140148442-A1 FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS ARENA PHARMACEUTICALS, INC. 2014-05-29 US disclosed
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-03-06 US disclosed
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US disclosed
US-20140051714-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US disclosed
US-20140038889-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-02-06 US disclosed
US-20130317005-A1 NON-HYGROSCOPIC SALTS OF 5-HT2C AGONISTS Arena Pharmaceuticals ,Inc 2013-11-28 US disclosed
US-20130315994-A1 MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT ARENA PHARMACEUTICALS, INC. 2013-11-28 US disclosed
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140038889-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, DPP4 SLC5A2 4/4885SLC5A1 5/4885
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, SLC5A2, SLC5A1 SLC5A2 2/4885SLC5A1 3/4885
US-20210330690-A1 TREATING UNTREATED OR TREATMENT-RESISTANT DIABETES WITH GLUCOKINASE ACTIVATOR AND SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITOR SLC5A2, SLC5A1, SLC2A1 SLC5A2 1/4885SLC5A1 2/4885
US-10463676-B2 Modified-release dosage forms of 5-HT2C agonists useful for weight management HTR2C, HTR2A, HTR3C SLC5A2 60/4885SLC5A1 118/4885
US-20130315994-A1 MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT HTR2C, HTR2A, HTR3C SLC5A2 60/4885SLC5A1 118/4885
US-11813274-B2 Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor SLC5A2, SLC5A1, SLC2A1 SLC5A2 1/4885SLC5A1 2/4885
US-20210340133-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, GLP1R, SLC5A2 SLC5A2 3/4885SLC5A1 5/4885
US-20140148442-A1 FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS HTR2C, HTR2A, HTR1A SLC5A2 135/4885SLC5A1 266/4885
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, GLP1R, DPP4 SLC5A2 4/4885SLC5A1 5/4885
US-20190275055-A1 Modified-Release Dosage Forms of 5-Ht2c Agonists Useful for Weight Management HTR2C, HTR2A, HTR3C SLC5A2 60/4885SLC5A1 118/4885
US-20140051714-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, DPP4 SLC5A2 4/4885SLC5A1 5/4885
US-10894787-B2 Modulators of the GPR119 receptor and the treatment of disorders related thereto GPR119, GLP1R, DPP9 SLC5A2 4/4885SLC5A1 6/4885
US-20230000816-A1 SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITORS FOR THE MANAGEMENT OF CHRONIC KIDNEY DISEASE, HYPERTENSION, AND HEART FAILURE IN COMPANION ANIMALS SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, SLC5A2 SLC5A2 3/4885SLC5A1 5/4885
US-20130317005-A1 NON-HYGROSCOPIC SALTS OF 5-HT2C AGONISTS HTR2C, HTR2A, HTR1A SLC5A2 120/4885SLC5A1 236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.