SCHEMBL14634839

SCHEMBL14634839

CCC(OC(=O)O)[C@@H]1O[C@@H](Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 19/20 0.67
SLC5A1 P13866 17/20 0.67
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14634838 0.94 SLC5A2 (0.70) SLC5A2SLC5A1
SCHEMBL14634840 0.94 SLC5A2 (0.70) SLC5A2SLC5A1
SCHEMBL173842 0.94 SLC5A2 (0.70) SLC5A2SLC5A1
SCHEMBL14634762 0.83 SLC5A2 (0.85) SLC5A2SLC5A1
SCHEMBL14862842 0.82 SLC5A2 (0.80) SLC5A2SLC5A1
SCHEMBL26892301 0.81 SLC5A2 (0.78) SLC5A2SLC5A1
Remogliflozin SCHEMBL18629778 0.81 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL3730054 0.81 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL17127189 0.81 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL18307653 0.81 SLC5A2 (1.00) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US claimed
US-20140051714-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US disclosed
US-20140018371-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-01-16 US disclosed
US-20130310369-A1 SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS ARENA PHARMACEUTICALS, INC 2013-11-21 US disclosed
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, SLC5A2, SLC5A1 SLC5A2 2/4885SLC5A1 3/4885LMNA 4368/4885
US-20130310369-A1 SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS CEL, HTR7, HTR1A SLC5A2 71/4885SLC5A1 46/4885LMNA 1048/4885
US-20140051714-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, DPP4 SLC5A2 4/4885SLC5A1 5/4885LMNA 4278/4885
US-20140018371-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GCGR, GLP1R SLC5A2 5/4885SLC5A1 6/4885LMNA 4194/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.