Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLTC | Q00610 | 2/20 | 0.76 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 10/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14636147 | 0.90 | CLTC (0.63) | CLTCCYP1B1MEN1USP2KMT2A | |
| SCHEMBL14636649 | 0.85 | CLTC (0.57) | CLTCCYP1B1MEN1USP2KMT2A | |
| SCHEMBL14636449 | 0.84 | CLTC (0.66) | CLTCCYP1B1MEN1USP2KMT2A | |
| SCHEMBL9006326 | 0.83 | CYP1B1 (0.61) | CLTCCYP1B1MEN1USP2KMT2A | |
| SCHEMBL29365854 | 0.80 | ALDH1A1 (0.54) | CLTCMEN1USP2KMT2AATM | |
| SCHEMBL9352299 | 0.80 | ALDH1A1 (0.54) | CLTCMEN1USP2KMT2AATM | |
| SCHEMBL12559609 | 0.78 | CLTC (0.49) | CLTCMEN1USP2KMT2AATM | |
| SCHEMBL25520072 | 0.77 | BRD4 (0.50) | CLTCCYP1B1MEN1USP2KMT2A | |
| SCHEMBL13428204 | 0.77 | CLTC (0.47) | CLTCMEN1USP2KMT2AKEAP1 | |
| SCHEMBL30608350 | 0.76 | TYMS (0.44) | CLTCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013010218-A9 | INHIBITION OF CLATHRIN | FREIE UNIVERSITÄT BERLIN (DE) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013010218-A9 | INHIBITION OF CLATHRIN | FREIE UNIVERSITÄT BERLIN (DE) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013010218-A1 | INHIBITION OF CLATHRIN | FREIE UNIVERSITÄT BERLIN (DE) | 2013-01-24 | — | — | WO | disclosed |
| WO-2013010218-A1 | INHIBITION OF CLATHRIN | FREIE UNIVERSITÄT BERLIN (DE) | 2013-01-24 | — | — | WO | disclosed |