Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12480062 | 0.80 | ALDH1A1 (0.48) | MAPTALDH1A1CYP3A4HSD17B10MAPK1 | |
| SCHEMBL4719832 | 0.76 | ALDH1A1 (0.46) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL30399809 | 0.76 | ALDH1A1 (0.46) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL14333666 | 0.76 | ALDH1A1 (0.46) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL221671 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL31104497 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL29179660 | 0.74 | HTT (0.45) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL17222837 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL1100650 | 0.74 | PIN1 (0.50) | MAPTALDH1A1LMNATDP1PIN1 | |
| SCHEMBL29811740 | 0.74 | PIN1 (0.50) | MAPTALDH1A1LMNATDP1PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3121177-B1 | COMBINATIONS OF TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-08-01 | — | — | EP | disclosed |
| EP-3121177-A1 | COMBINATIONS OF TRPV4 ANTAGONISTS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-01-25 | — | — | EP | disclosed |
| EP-2721016-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-04-06 | — | — | EP | disclosed |
| US-9187464-B2 | TRPV4 antagonists | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20140121206-A1 | TRPV4 ANTAGONISTS | GlaxoSmithKliine, LLC (US) | 2014-05-01 | — | — | US | disclosed |
| EP-2721016-A1 | TRPV4 ANTAGONISTS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-04-23 | — | — | EP | disclosed |
| WO-2013012500-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2013-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140121206-A1 | TRPV4 ANTAGONISTS | TRPV4, TRPV3, TRPV5 | MAPT 2993/4885ALDH1A1 2000/4885LMNA 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.