Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20627764 | 0.85 | FGFR1 (0.49) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20627045 | 0.85 | FGFR1 (0.49) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL25487479 | 0.84 | SMN1; SMN2 (0.47) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19350865 | 0.83 | FGFR1 (0.55) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20627475 | 0.81 | NPC1 (0.47) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29505576 | 0.81 | SMN1; SMN2 (0.65) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4590705 | 0.79 | FGFR1 (0.74) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29357610 | 0.79 | FGFR1 (1.00) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7989819 | 0.79 | FGFR1 (1.00) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20627049 | 0.79 | AURKA (0.50) | FGFR1HPGDSMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017152874-A1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2017-09-14 | — | — | WO | disclosed |
| EP-2565185-A1 | [5,6]HETEROCYCLIC COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20130029964-A1 | [5, 6] HETEROCYCLIC COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-01-31 | — | — | US | disclosed |
| US-20130029964-A1 | [5, 6] HETEROCYCLIC COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-01-31 | — | — | US | disclosed |
| US-20130029964-A1 | [5, 6] HETEROCYCLIC COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029964-A1 | [5, 6] HETEROCYCLIC COMPOUND | BMP2, BMP4, SOST | FGFR1 128/4885HPGD 1022/4885SMN1; SMN2 1778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.