Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NSD2 | O96028 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | FGR | P09769 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711022 | 0.82 | CDC25B (0.65) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL29633565 | 0.82 | CDC25B (0.65) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL29563346 | 0.82 | RAB9A (0.68) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL1510327 | 0.82 | RAB9A (0.68) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL16745451 | 0.75 | RAB9A (0.60) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL6297709 | 0.73 | MAPT (0.56) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL14660371 | 0.71 | ALDH1A1 (1.00) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL10068411 | 0.71 | P2RX7 (0.72) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL228422 | 0.71 | CDC25B (0.56) | NPC1RAB9AALDH1A1NSD2POLB | |
| SCHEMBL6861561 | 0.71 | APAF1 (0.61) | NPC1RAB9AALDH1A1NSD2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113372298-B | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2022-04-19 | — | — | CN | claimed |
| CN-113372298-A | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2021-09-10 | — | — | CN | claimed |
| CN-113372298-B | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-113372298-B | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-113372298-B | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-113372298-A | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2021-09-10 | — | — | CN | disclosed |
| CN-113372298-A | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2021-09-10 | — | — | CN | disclosed |
| CN-113372298-A | Preparation method of 2-iodine-3-amino naphthoquinone compound | 温州医科大学 | 2021-09-10 | — | — | CN | disclosed |
| US-9422231-B2 | Method for inhibiting Trypanosoma cruzi | HOWARD UNIVERSITY (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150073177-A1 | METHOD FOR INHIBITING TRYPANOSOMA CRUZI | HOWARD UNIVERRSITY (US) | 2015-03-12 | — | — | US | disclosed |
| US-20140336187-A1 | METHODS FOR TREATING LEISHMANIASIS | HOWARD UNIVERSITY | 2014-11-13 | — | — | US | disclosed |
| WO-2013074930-A1 | METHODS FOR TREATING LEISHMANIASIS | HOWARD UNIVERSITY (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013016661-A1 | METHOD FOR INHIBITING TRYPANSOMA CRUZI | HOWARD UNIVERSITY (US) | 2013-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336187-A1 | METHODS FOR TREATING LEISHMANIASIS | LSS, CYP51A1, NQO1 | NPC1 398/4885RAB9A 1800/4885ALDH1A1 911/4885 |
| US-20150073177-A1 | METHOD FOR INHIBITING TRYPANOSOMA CRUZI | PCNA, NQO1, NQO2 | NPC1 2567/4885RAB9A 2478/4885ALDH1A1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.