Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | BRD2 | P25440 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28190146 | 0.81 | BRD4 (0.60) | PTGS1PTGS2BRD4BRD2HSD17B10 | |
| SCHEMBL16404611 | 0.78 | BRD4 (0.56) | PTGS1PTGS2BRD4BRD2HSD17B10 | |
| SCHEMBL16429065 | 0.78 | BRD4 (0.56) | PTGS1PTGS2BRD4BRD2HSD17B10 | |
| Hydrochloric Acid SCHEMBL23174958 | 0.76 | BRD4 (0.55) | PTGS1PTGS2BRD4BRD2HSD17B10 | |
| SCHEMBL18249919 | 0.76 | NR3C1 (0.43) | PTGS1PTGS2BRD4BRD2TSHR | |
| SCHEMBL2281131 | 0.76 | PTGS1 (1.00) | PTGS1PTGS2BRD4BRD2HSD17B10 | |
| SCHEMBL593750 | 0.75 | DHFR (0.55) | BRD4BRD2HSD17B10LMNAALDH1A1 | |
| SCHEMBL13232505 | 0.75 | BRD4 (0.53) | PTGS1PTGS2BRD4BRD2HSD17B10 | |
| SCHEMBL16257337 | 0.75 | BRD4 (0.53) | BRD4BRD2HSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL17833812 | 0.75 | BRD4 (0.53) | BRD4BRD2HSD17B10LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256740-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| EP-2747560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013085890-A1 | THERAPEUTIC METHODS | GLAXO GROUP LIMITED (GB) | 2013-06-13 | — | — | WO | disclosed |
| WO-2013019635-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256740-A1 | COMPOUNDS AND METHODS | RORC, RORB, RORA | PTGS1 1470/4885PTGS2 1562/4885BRD4 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.