SCHEMBL14698357

SCHEMBL14698357

CC(C)OC(=O)c1ccc(C(F)(F)F)cc1-c1ncccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 8/20 0.46
▸ GPBAR1 Q8TDU6 1/20 0.45
▸ MAPT P10636 3/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ LMNA P02545 3/20 0.39
▸ GAA P10253 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ TP53 P04637 1/20 0.38
▸ PDK2 Q15119 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14697616 0.82 GPBAR1 (0.50) TRPV1GPBAR1
SCHEMBL14697587 0.82 TRPV1 (0.49) TRPV1GPBAR1KDM4ELMNAHPGD
SCHEMBL27961391 0.70 CFTR (0.47) MAPTKDM4ENPSR1LMNAGAA
SCHEMBL955971 0.69 KDM4E (0.48) MAPTKDM4ELMNAGAAHPGD
SCHEMBL7249540 0.69 CFTR (0.46) MAPTKDM4ENPSR1LMNAGAA
SCHEMBL343871 0.69 BACE1 (0.48) PDK2
SCHEMBL2302131 0.69 CES2 (0.47) KDM4ENPSR1LMNAGAAHPGD
SCHEMBL28011915 0.69 CA12 (0.64) KDM4ELMNAHPGDTHRB
SCHEMBL6769661 0.68 PDK2 (0.46) KDM4EPOLBL3MBTL1LMNAPDK2
SCHEMBL2223051 0.68 LMNA (0.56) MAPTKDM4EPOLBNPSR1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140243195-A1 N-Thio-anthranilamide compounds and their use as pesticides BASF SE (DE) 2014-08-28 — — US disclosed
CN-103889955-A N-thio-anthranilamide compounds and their use as pesticides BASF SE 2014-06-25 — — CN disclosed
EP-2742022-A1 ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-06-18 — — EP disclosed
EP-2742023-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-06-18 — — EP disclosed
CN-103842342-A Anthranilamide compounds and their use as pesticides BASF SE 2014-06-04 — — CN disclosed
WO-2013024005-A1 ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2013-02-21 — — WO disclosed
WO-2013024003-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2013-02-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243195-A1 N-Thio-anthranilamide compounds and their use as pesticides ANTXR2, NIT2, TXN TRPV1 1334/4885GPBAR1 4030/4885MAPT 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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