SCHEMBL14701251

SCHEMBL14701251

C=C(C)C(=O)OCOC(=O)c1ccc(C(C)(O)C(F)(F)F)c2ccccc12

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KCNJ11 Q14654 12/20 0.35
ABCC9 O60706 5/20 0.35
ABCC8 Q09428 5/20 0.35
KCNJ8 Q15842 5/20 0.35
ADRB2 P07550 1/20 0.31
ADRB1 P08588 1/20 0.31
ADRB3 P13945 1/20 0.31
KDM4E B2RXH2 2/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14701241 0.88 ADRB2 (0.33) ADRB2ADRB1ADRB3KDM4ETSHR
SCHEMBL14701246 0.79 KDM4E (0.33) KCNJ11ABCC9ABCC8KCNJ8KDM4E
SCHEMBL14701264 0.75 KMT2A (0.34) KDM4EKMT2AATMTSHR
SCHEMBL28886899 0.74 TSHR (0.53) TSHR
SCHEMBL18904535 0.74 CDC25B (0.52) ADRB2ADRB1ADRB3KDM4EKMT2A
SCHEMBL18904519 0.73 CDC25B (0.46) ADRB2ADRB1ADRB3KMT2ATSHR
SCHEMBL14701245 0.71 KDM4E (0.32) KDM4EKMT2ATSHR
SCHEMBL17124659 0.70 TSHR (0.44) KMT2ATSHR
SCHEMBL18904507 0.70 CDC25B (0.36) ADRB2ADRB1ADRB3KDM4EKMT2A
SCHEMBL8413374 0.69 TDP1 (0.54) ADRB2ADRB1ADRB3KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9040225-B2 Developable bottom antireflective coating composition and pattern forming method using thereof INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2015-05-26 US disclosed
US-8715907-B2 Developable bottom antireflective coating compositions for negative resists INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2014-05-06 US disclosed
US-20130040238-A1 DEVELOPABLE BOTTOM ANTIREFLECTIVE COATING COMPOSITIONS FOR NEGATIVE RESISTS INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2013-02-14 US disclosed