Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14701896 | 0.93 | PPARG (0.50) | PPARGPPARAGAAL3MBTL1IDO1 | |
| SCHEMBL8932405 | 0.88 | PPARG (0.52) | PPARGPPARAGAAL3MBTL1IDO1 | |
| SCHEMBL14701898 | 0.76 | EPHX1 (0.43) | GAAL3MBTL1IDO1ACEEPHX1 | |
| SCHEMBL7411635 | 0.73 | PPARG (0.47) | PPARGPPARAGAAL3MBTL1IDO1 | |
| SCHEMBL10511874 | 0.73 | PPARG (0.62) | PPARGPPARAGAAACECACNA1B | |
| SCHEMBL10641625 | 0.72 | GAA (0.51) | PPARGPPARAGAAIDO1EPHX1 | |
| SCHEMBL7870056 | 0.72 | PPARG (0.57) | PPARGPPARAGAAL3MBTL1ACE | |
| SCHEMBL22062857 | 0.72 | ALDH1A1 (0.46) | PPARGPPARAL3MBTL1ALDH1A1LMNA | |
| SCHEMBL15745439 | 0.71 | MEN1 (0.43) | GAASYKSERPINE1KMT2AMEN1 | |
| SCHEMBL15745436 | 0.71 | MEN1 (0.43) | GAASYKSERPINE1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160002286-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY | 2016-01-07 | — | — | US | disclosed |
| US-9175053-B2 | Chemical preparation of ubiquitin thioesters and modifications thereof | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2015-11-03 | — | — | US | disclosed |
| US-20130041132-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002286-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | OTUB1, USP28, PTMS | PPARG 4191/4885PPARA 2818/4885GAA 1281/4885 |
| US-20130041132-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | OTUB1, USP28, PTMS | PPARG 4191/4885PPARA 2818/4885GAA 1281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.