Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12900870 | 1.00 | TSHR (0.45) | TSHRHPGDRECQLRAB9ASMN1; SMN2 | |
| SCHEMBL9887648 | 1.00 | TSHR (0.45) | TSHRHPGDRECQLRAB9ASMN1; SMN2 | |
| SCHEMBL19625142 | 0.76 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL23020652 | 0.74 | HPGD (0.57) | TSHRHPGDRECQLSMN1; SMN2CYP3A4 | |
| SCHEMBL20879998 | 0.74 | HPGD (0.57) | TSHRHPGDRECQLSMN1; SMN2CYP3A4 | |
| SCHEMBL47623 | 0.73 | TSHR (0.43) | TSHRHPGDRECQLRAB9ASMN1; SMN2 | |
| SCHEMBL47662 | 0.73 | TSHR (0.43) | TSHRHPGDRECQLRAB9ASMN1; SMN2 | |
| SCHEMBL18773876 | 0.69 | TRPM8 (0.46) | TSHRSMN1; SMN2KMT2AALDH1A1CYP1A2 | |
| SCHEMBL17468873 | 0.68 | SMN1; SMN2 (0.41) | TSHRRAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL14981005 | 0.68 | CTSB (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024048-A1 | POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS | ASCENDIS PHARMA A/S (DK) | 2013-02-21 | — | — | WO | disclosed |
| WO-2013024047-A1 | HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS | ASCENDIS PHARMA A/S (DK) | 2013-02-21 | — | — | WO | disclosed |
| WO-2013024049-A1 | PROTEIN CARRIER-LINKED PRODRUGS | ASCENDIS PHARMA A/S (DK) | 2013-02-21 | — | — | WO | disclosed |