Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formaldehyde SCHEMBL1471574 | 0.83 | PRMT6 (0.50) | MAPTCYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1471423 | 0.80 | ALDH1A1 (0.47) | MAPTCYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1470938 | 0.77 | KAT2B (0.61) | MAPTMAPK1ALDH1A1HTTKMT2A | |
| SCHEMBL1471422 | 0.77 | PRMT6 (0.53) | MAPTCYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1473120 | 0.75 | MAPT (0.40) | MAPTCYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL14960166 | 0.73 | KAT2B (0.53) | MAPTMAPK1ALDH1A1HTTLMNA | |
| SCHEMBL31361985 | 0.72 | MAPT (0.82) | MAPTCYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL7170786 | 0.70 | MAPT (0.68) | MAPTCYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL5550215 | 0.70 | KAT2B (0.55) | MAPTMAPK1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6198859 | 0.70 | KAT2B (0.80) | MAPTMAPK1ALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915420-B2 | Aryl piperidine amides | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-29 | — | — | US | disclosed |
| US-20080009521-A1 | Aryl Piperidine Amides | HUANG CHARLES Q | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009521-A1 | Aryl Piperidine Amides | BDNF, NTRK2, OPRL1 | MAPT 898/4885CYP1A2 2066/4885CYP2C9 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.