Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.37 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | S100B | P04271 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1471375 | 0.81 | ADRA1D (0.38) | MAPTMAPK1ALDH1A1LMNATDP1 | |
| SCHEMBL1470738 | 0.80 | HPGD (0.42) | MAPTMAPK1ALDH1A1KMT2AALOX15 | |
| SCHEMBL1471413 | 0.71 | KDM4E (0.32) | MAPTGAAKDM4E | |
| SCHEMBL5884397 | 0.66 | DRD3 (0.57) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1470779 | 0.66 | RAB9A (0.47) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6201094 | 0.66 | MAPT (0.52) | HDAC4MAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL1470996 | 0.66 | MEN1 (0.61) | MAPTALDH1A1LMNATDP1MEN1 | |
| SCHEMBL11722763 | 0.64 | DRD3 (0.59) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL11713412 | 0.64 | HRH3 (0.56) | — | |
| Formaldehyde SCHEMBL1471574 | 0.63 | PRMT6 (0.50) | HDAC4MEF2DMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915420-B2 | Aryl piperidine amides | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-29 | — | — | US | claimed |