Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 12/20 | 0.48 |
| ▸ | WHR1 | P49842 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 3/20 | 0.46 |
| ▸ | NSD3 | Q9BZ95 | 3/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715393 | 0.91 | EHMT2 (0.45) | EHMT2WHR1NSD2NSD3EHMT1 | |
| SCHEMBL14715370 | 0.90 | EHMT2 (0.44) | EHMT2NSD2NSD3EHMT1DNMT3A | |
| SCHEMBL14715448 | 0.88 | ADRA2A (0.47) | EHMT2WHR1EHMT1ADRA1DADRA1A | |
| SCHEMBL2172355 | 0.87 | EHMT2 (0.49) | EHMT2WHR1NSD2NSD3EHMT1 | |
| SCHEMBL14715376 | 0.87 | WHR1 (0.46) | EHMT2WHR1EHMT1ADRA1AADRA1B | |
| SCHEMBL14715446 | 0.86 | WHR1 (0.49) | EHMT2WHR1ADRA1DADRA1AADRA1B | |
| SCHEMBL14715472 | 0.84 | ADRA1A (0.44) | EHMT2WHR1NSD2NSD3EHMT1 | |
| SCHEMBL14715455 | 0.83 | ADRA1A (0.55) | ADRA1DADRA1AADRA1B | |
| SCHEMBL14715298 | 0.82 | WHR1 (0.44) | EHMT2WHR1EHMT1ADRA1AADRA1B | |
| SCHEMBL14715427 | 0.82 | PDGFRB (0.43) | WHR1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346848-B1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |