Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 11/20 | 0.89 |
| ▸ | KCNK9 | Q9NPC2 | 9/20 | 0.89 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298254 | 0.94 | KCNK3 (1.00) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL14715912 | 0.90 | KCNK3 (0.92) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL14715827 | 0.90 | KCNK3 (0.92) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL14715832 | 0.88 | KCNK3 (0.88) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL19491390 | 0.87 | SIRT1 (1.00) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL14715821 | 0.86 | KCNK3 (0.85) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL15177198 | 0.86 | KCNK3 (0.77) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL18953510 | 0.86 | RAB9A (0.78) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL22305399 | 0.86 | KCNK3 (0.83) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL11858223 | 0.85 | GPR35 (0.67) | KCNK3KCNK9SIRT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017098421-A1 | BENZOTHIADIAZINE COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |