Phentydrone

Phentydrone

SCHEMBL147182

ClCCl.O=C1C2=C(CCCC2)c2ccccc21

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CDC25B P30305 2/20 0.48
IDO1 P14902 2/20 0.41
DNMT1 P26358 2/20 0.41
DNMT3L Q9UJW3 1/20 0.41
DNMT3A Q9Y6K1 1/20 0.41
MAOA P21397 4/20 0.41
MAPT P10636 3/20 0.41
MAPK1 P28482 3/20 0.41
NPC1 O15118 2/20 0.41
LMNA P02545 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CES1 P23141 2/20 0.41
APAF1 O14727 2/20 0.41
TDP2 O95551 2/20 0.41
S100A4 P26447 2/20 0.41
KDM4E B2RXH2 1/20 0.41
CES2 O00748 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phentydrone SCHEMBL875187 0.92 MEN1 (0.57) MEN1KMT2ACDC25BIDO1DNMT1
Phentydrone SCHEMBL7556165 0.90 MEN1 (0.39) MEN1KMT2ACDC25BIDO1DNMT1
Phentydrone SCHEMBL5213043 0.90 CDC25B (0.39) MEN1KMT2ACDC25BMAOAMAPT
Anthraquinone SCHEMBL11352939 0.89 MEN1 (0.60) MEN1KMT2ACDC25BIDO1DNMT1
SCHEMBL545308 0.87 MEN1 (0.55) MEN1KMT2ACDC25BIDO1DNMT1
SCHEMBL29519720 0.87 MEN1 (0.55) MEN1KMT2ACDC25BIDO1DNMT1
Phentydrone SCHEMBL9628384 0.86 MEN1 (0.50) MEN1KMT2ACDC25BIDO1DNMT1
SCHEMBL10697306 0.85 MEN1 (0.52) MEN1KMT2ACDC25BIDO1DNMT1
SCHEMBL29080974 0.85 CDC25B (0.52) MEN1KMT2ACDC25BIDO1DNMT1
SCHEMBL10697311 0.85 MEN1 (0.52) MEN1KMT2ACDC25BIDO1DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240173303-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase INCYTE HOLDINGS CORPORATION 2024-05-30 US disclosed
EP-3893645-B1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (CA) 2024-04-17 EP disclosed
EP-2911669-B1 SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER UNIV CHICAGO (US) 2024-04-10 EP disclosed
US-11939291-B2 GRP94 selective inhibitors and uses thereof UNIVERSITY OF KANSAS (US) 2024-03-26 US disclosed
US-20230045421-A1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (CA) 2023-02-09 US disclosed
US-20220024869-A1 GRP94 SELECTIVE INHIBITORS AND USES THEREOF UNIVERSITY OF KANSAS 2022-01-27 US disclosed
US-11207302-B2 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2021-12-28 US disclosed
US-11158820-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2021-10-26 US disclosed
EP-3893645-A1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2021-10-20 EP disclosed
US-20210228715-A1 SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER THE UNIVERSITY OF CHICAGO (US) 2021-07-29 US disclosed
EP-1005446-A1 N-AROYLPHENYLALANINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-06-07 EP disclosed
EP-0995755-A1 Prodrugs of Thrombin inhibitors Astra Aktiebolag (SE) 2000-04-26 EP disclosed
US-5965692-A ANTICOAGULANTS FOR TREATMENT OF THROMOBOSIS AND HYPERCOAGULABILITY IN BLOOD AND TISSUES ASTRA AB (SE) 1999-10-12 US disclosed
US-5912352-A CATALYTIC REDUCTION OF HYDRAZIDE TO HYDRAZINE DERIVATIVE IN PRESENCE OF COMPLEX HYDRIDE; ACYL MIGRATION; HYDROGENATION; CATALYST SELECTIVITY NOVARTIS FINANCE CORPORATION (US) 1999-06-15 US disclosed
WO-1999014226-A2 BI- AND TRI-CYCLIC NUCLEOSIDE, NUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES EXIQON A/S (DK) 1999-03-25 WO disclosed
WO-1999010313-A1 N-AROYLPHENYLALANINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 1999-03-04 WO disclosed
EP-0869966-A1 PRODRUGS OF THROMBIN INHIBITORS Astra Aktiebolag (SE) 1998-10-14 EP disclosed
WO-1997046514-A1 PROCESS FOR THE PREPARATION OF HYDRAZINE DERIVATIVES USEFUL AS INTERMEDIATES FOR THE PREPARATION OF PEPTIDE ANALOGUES NOVARTIS AG (CH) 1997-12-11 WO disclosed
WO-1997023499-A1 PRODRUGS OF THROMBIN INHIBITORS ASTRA AKTIEBOLAG (SE) 1997-07-03 WO disclosed
US-4277601-A Preparation of sodium cefuroxime GLAXO GROUP LIMITED (GB) 1981-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240173303-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase IDO1, IDO2, INMT MEN1 1453/4885KMT2A 1071/4885CDC25B 393/4885
US-11207302-B2 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase IDO1, IDO2, INMT MEN1 1453/4885KMT2A 1071/4885CDC25B 393/4885
US-20210228715-A1 SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER ICOS, CD274, IDO1 MEN1 3083/4885KMT2A 792/4885CDC25B 273/4885
US-11939291-B2 GRP94 selective inhibitors and uses thereof GRPR, HSP90B1, HSPE1 MEN1 2921/4885KMT2A 4860/4885CDC25B 1566/4885
US-11158820-B2 Organic electroluminescent materials and devices TPR, PIR, PPOX MEN1 2090/4885KMT2A 3121/4885CDC25B 2287/4885
US-20220024869-A1 GRP94 SELECTIVE INHIBITORS AND USES THEREOF GRPR, HSP90B1, HSPE1 MEN1 2921/4885KMT2A 4860/4885CDC25B 1566/4885
US-20230045421-A1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME HAVCR2, HMBS, AHCY MEN1 1955/4885KMT2A 271/4885CDC25B 1426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.