Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14728258 | 0.85 | REN (0.39) | KMT2AMEN1P2RX7MAPK14POLB | |
| SCHEMBL14720556 | 0.77 | PNMT (0.41) | KMT2AMEN1P2RX7SLC22A12POLB | |
| SCHEMBL14720172 | 0.76 | MEN1 (0.40) | KMT2AMEN1P2RX7POLBNPSR1 | |
| SCHEMBL15844079 | 0.75 | P2RX7 (0.37) | KMT2AMEN1P2RX7SLC22A12MAPK14 | |
| SCHEMBL27873445 | 0.66 | TSHR (0.61) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| SCHEMBL20356564 | 0.64 | CCR4 (0.40) | KMT2AMEN1P2RX7SLC22A12PKM | |
| SCHEMBL11406992 | 0.63 | RAB9A (0.41) | KMT2AMEN1ALDH1A1HTTLMNA | |
| SCHEMBL20356755 | 0.63 | CCR4 (0.38) | KMT2AMEN1SLC22A12NPSR1SMN1; SMN2 | |
| SCHEMBL10802129 | 0.62 | PNMT (0.48) | KMT2AMEN1P2RX7POLBALDH1A1 | |
| SCHEMBL9642442 | 0.62 | P2RX7 (0.50) | KMT2AMEN1P2RX7NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |