Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14728435 | 0.83 | REN (0.42) | MEN1KMT2AP2RX7POLB | |
| SCHEMBL14720231 | 0.76 | PNMT (0.43) | MEN1KMT2ASMN1; SMN2NR3C1AKR1B1 | |
| SCHEMBL14720153 | 0.76 | KMT2A (0.41) | MEN1KMT2ASMN1; SMN2NPSR1NR3C1 | |
| SCHEMBL15844226 | 0.73 | NR3C1 (0.37) | MEN1KMT2ASMN1; SMN2NPSR1NR3C1 | |
| SCHEMBL27873445 | 0.68 | TSHR (0.61) | MEN1KMT2ASMN1; SMN2NPSR1NR3C1 | |
| SCHEMBL14720127 | 0.65 | PNMT (0.43) | SMN1; SMN2NR3C1P2RX7AKR1B1 | |
| SCHEMBL14720422 | 0.64 | PNMT (0.46) | SMN1; SMN2NR3C1AKR1B1ALDH1A1 | |
| SCHEMBL3302008 | 0.63 | PNMT (0.68) | MEN1KMT2AALDH1A1POLB | |
| SCHEMBL14720145 | 0.63 | PNMT (0.41) | SMN1; SMN2NR3C1AKR1B1 | |
| SCHEMBL2547244 | 0.63 | AKR1B1 (0.63) | SMN1; SMN2NPSR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |