Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.72 |
| ▸ | DRD3 | P35462 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.69 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.67 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.67 |
| ▸ | HTR7 | P34969 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15835899 | 0.92 | DRD2 (0.80) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL14722227 | 0.91 | DRD2 (0.86) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL9433700 | 0.90 | OPRM1 (0.67) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL27246707 | 0.87 | HDAC3 (0.61) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL4664187 | 0.86 | OPRM1 (0.66) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL9433423 | 0.85 | SMN1; SMN2 (0.73) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL9434806 | 0.84 | PRMT5 (0.71) | DRD2DRD3OPRM1PRMT5WDR77 | |
| SCHEMBL13135946 | 0.83 | ALOX15 (0.62) | DRD2DRD3OPRM1HTR7SIGMAR1 | |
| SCHEMBL10722398 | 0.82 | HPGD (0.67) | HPGDHDAC8KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8425898 | 0.82 | DRD2 (0.57) | DRD2DRD3OPRM1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| CN-107260726-A | Composition and method for treating nerve degenerative diseases | 考格尼申治疗股份有限公司 | 2017-10-20 | — | — | CN | disclosed |
| US-20140378460-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| CN-104053436-A | Compositions and methods for treating neurodegenerative diseases | COGNITION THERAPEUTICS INC | 2014-09-17 | — | — | CN | disclosed |
| EP-2747768-A2 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | Cognition Therapeutics, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013029060-A2 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378460-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | TMEM97, SLC18A2, SIGMAR1 | DRD2 164/4885DRD3 475/4885OPRM1 127/4885 |
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | TMEM97, SLC18A2, SIGMAR1 | DRD2 164/4885DRD3 475/4885OPRM1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.