Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720609 | 0.90 | DRD2 (0.72) | OPRM1DRD2DRD3OPRK1HPGD | |
| SCHEMBL9433423 | 0.83 | SMN1; SMN2 (0.73) | OPRM1DRD2DRD3ABCB1ABCG2 | |
| SCHEMBL15835899 | 0.82 | DRD2 (0.80) | OPRM1DRD2DRD3HPGDPRMT5 | |
| SCHEMBL9433141 | 0.82 | ABCB1 (0.69) | DRD2DRD3ABCB1ABCG2SIGMAR1 | |
| SCHEMBL9434806 | 0.82 | PRMT5 (0.71) | OPRM1DRD2DRD3ABCB1ABCG2 | |
| SCHEMBL14722227 | 0.81 | DRD2 (0.86) | OPRM1DRD2DRD3PRMT5WDR77 | |
| SCHEMBL27246707 | 0.80 | HDAC3 (0.61) | OPRM1DRD2DRD3PRMT5WDR77 | |
| SCHEMBL4664187 | 0.80 | OPRM1 (0.66) | OPRM1DRD2DRD3PRMT5WDR77 | |
| SCHEMBL13135946 | 0.79 | ALOX15 (0.62) | OPRM1DRD2DRD3MEN1KMT2A | |
| SCHEMBL3408343 | 0.78 | ALDH1A1 (0.71) | HPGDCD274MEN1KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294621-A | Thieno tetrahydropyridines useful as class III antiarrhythmic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |