Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720494 | 0.86 | LMNA (0.33) | CHRM3HDAC8LMNAPTGIR | |
| SCHEMBL14720616 | 0.79 | LIMK2 (0.36) | ACHEOPRD1 | |
| SCHEMBL14720171 | 0.77 | CNR1 (0.33) | CHRM3CHRM2LMNAOPRD1 | |
| SCHEMBL14720449 | 0.74 | CHRM3 (0.52) | CHRM3HTTGAATSHRACHE | |
| SCHEMBL14720167 | 0.72 | CYP3A4 (0.46) | TSHRLMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14720417 | 0.70 | HDAC3 (0.41) | HDAC8HDAC6LMNAMAPT | |
| SCHEMBL2194496 | 0.69 | TSHR (0.70) | CHRM3HTTGAATSHRTRPV1 | |
| SCHEMBL14720555 | 0.67 | FASN (0.37) | — | |
| SCHEMBL14720215 | 0.63 | GRIN2B (0.44) | CHRM3GAALMNAMAPTCYP3A4 | |
| SCHEMBL13757418 | 0.62 | HDAC8 (0.46) | HTTGAATSHRHDAC8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |