Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720920 | 0.81 | HRH3 (0.47) | GPR183KCNH2MCHR1HRH3L3MBTL3 | |
| SCHEMBL14720608 | 0.81 | HRH3 (0.43) | GPR183KCNH2MCHR1HRH3L3MBTL3 | |
| SCHEMBL14721159 | 0.78 | L3MBTL3 (0.51) | KCNH2ALDH1A1L3MBTL3L3MBTL1KMT2A | |
| SCHEMBL14722836 | 0.77 | HRH3 (0.41) | GPR183KCNH2MCHR1HRH3L3MBTL3 | |
| SCHEMBL14722284 | 0.77 | HRH3 (0.44) | GPR183KCNH2MCHR1HRH3L3MBTL3 | |
| SCHEMBL14720798 | 0.76 | SRD5A2 (0.32) | KMT2ASRD5A2 | |
| SCHEMBL14720311 | 0.75 | MCHR1 (0.38) | GPR183MCHR1ALDH1A1HRH3L3MBTL3 | |
| SCHEMBL14721035 | 0.75 | MCHR1 (0.36) | MCHR1HRH3L3MBTL3L3MBTL1SRD5A2 | |
| SCHEMBL14721158 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KMT2A | |
| SCHEMBL14721773 | 0.74 | ALDH1A3 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |