Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 7/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14723616 | 0.86 | LMNA (0.42) | DAOSMN1; SMN2L3MBTL1KMT2ALMNA | |
| SCHEMBL14722466 | 0.81 | DAO (0.46) | DAOPOLBKMT2A | |
| SCHEMBL14722416 | 0.78 | DAO (0.48) | DAOSMN1; SMN2GPR84ALDH1A1KMT2A | |
| SCHEMBL14722542 | 0.73 | DAO (0.49) | DAOALDH1A1AKR1B1KMT2ALMNA | |
| SCHEMBL10507388 | 0.72 | ALDH1A1 (0.46) | DAOPKMSMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL14722008 | 0.72 | DAO (0.42) | DAOSMN1; SMN2ROCK2ROCK1ALDH1A1 | |
| SCHEMBL14721093 | 0.71 | MAPT (0.43) | DAOSMN1; SMN2GPR84ALDH1A1LMNA | |
| SCHEMBL14723525 | 0.71 | DAO (0.49) | DAO | |
| SCHEMBL14722889 | 0.70 | RNASEH1 (0.43) | DAOPKMCYP1A2L3MBTL1ALDH1A1 | |
| SCHEMBL2322736 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748149-A1 | PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013027000-A1 | PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |