Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722803 | 0.86 | DAO (0.47) | LMNAKMT2ADAOSMN1; SMN2L3MBTL1 | |
| SCHEMBL14721093 | 0.84 | MAPT (0.43) | LMNAMAPTDAOSMN1; SMN2PDE3B | |
| SCHEMBL14722889 | 0.84 | RNASEH1 (0.43) | DAOL3MBTL1 | |
| SCHEMBL28815273 | 0.73 | LMNA (0.40) | LMNAMEN1KMT2AMAPT | |
| SCHEMBL14722466 | 0.71 | DAO (0.46) | KMT2ADAO | |
| SCHEMBL2322736 | 0.68 | — | — | |
| SCHEMBL28338493 | 0.67 | ALDH1A1 (0.41) | MEN1KMT2AMAPTDAOSMN1; SMN2 | |
| SCHEMBL21325388 | 0.67 | ALDH1A1 (0.34) | — | |
| SCHEMBL5206921 | 0.66 | PLA2G7 (0.49) | DAOPDE3BPDE3APLA2G7 | |
| SCHEMBL14719355 | 0.66 | LMNA (0.49) | LMNAMEN1KMT2AMAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748149-A1 | PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013027000-A1 | PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |