Damnacanthal

Damnacanthal

SCHEMBL147246

COc1c(C=O)c(O)cc2c1C(=O)c1ccccc1C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 1.00
▸ ALDH1A1 P00352 2/20 1.00
▸ LCK P06239 1/20 1.00
▸ GLA P06280 1/20 1.00
▸ THRB P10828 1/20 1.00
▸ LIMK1 P53667 1/20 1.00
▸ LIMK2 P53671 1/20 1.00
▸ BCL2 P10415 3/20 0.50
▸ MCL1 Q07820 3/20 0.50
▸ NPC1 O15118 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ MEN1 O00255 4/20 0.46
▸ KMT2A Q03164 4/20 0.46
▸ PKLR P30613 2/20 0.44
▸ TDP1 Q9NUW8 2/20 0.43
▸ AR P10275 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42
▸ USP2 O75604 1/20 0.42
▸ DUSP3 P51452 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Damnacanthal SCHEMBL29356591 1.00 MAPT (1.00) MAPTALDH1A1LCKGLATHRB
SCHEMBL16226525 0.89 ALDH1A1 (0.80) MAPTALDH1A1LCKGLATHRB
SCHEMBL16225884 0.84 MAPT (0.72) MAPTALDH1A1LCKGLATHRB
SCHEMBL8341400 0.82 MAPT (0.69) MAPTALDH1A1LCKGLATHRB
SCHEMBL16227041 0.81 MAPT (0.68) MAPTALDH1A1LCKGLATHRB
SCHEMBL30407933 0.80 BCL2 (0.67) MAPTALDH1A1LCKGLATHRB
SCHEMBL16227182 0.80 BCL2 (0.67) MAPTALDH1A1LCKGLATHRB
SCHEMBL1149730 0.79 MAPT (0.66) MAPTALDH1A1LCKGLATHRB
SCHEMBL18601895 0.79 MAPT (0.65) MAPTALDH1A1LCKGLATHRB
SCHEMBL29066464 0.78 MAPT (0.63) MAPTALDH1A1LCKGLATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1218 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250360129-A1 COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS UNIV YALE (US) 2025-11-27 — — US claimed
EP-3250192-B1 COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS UNIV YALE (US) 2025-10-08 — — EP claimed
US-20250122295-A1 METHOD OF TREATMENT OF PHILADELPHIA CHROMOSOME POSITIVE LEUKEMIA CSL LIMITED (AU) 2025-04-17 — — US claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 — — US claimed
WO-2024111000-A1 AN ANTI-CANCER COMPOSITION OF HERBAL EXTRACTS AND ITS METHOD OF PREPARATION THEREOF M/S VALYOU PRODUCTS PRIVATE LIMITED (IN) 2024-05-30 — — WO claimed
US-20230148436-A2 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF SHENZHEN UNIVERSITY (CN) 2023-05-11 — — US claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 — — US claimed
US-20230036788-A1 COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS UNIV YALE (US) 2023-02-02 — — US claimed
CN-115245533-A Application of south mountain flower root extract in pulmonary fibrosis treatment 中国医学科学院药物研究所 2022-10-28 — — CN claimed
CN-115192726-A Synthesis of immune agonist targeting compound and application thereof 深圳大学 2022-10-18 — — CN claimed
JP-2005533604-A — — 2005-11-10 — — JP claimed
US-20050203612-A1 Luminal prostheses which allow for programmed and controlled delivery of mycophenolic acid or derivatives with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis and hyperplasia AVANTEC VASCULAR CORPORATION (US) 2005-09-15 — — US claimed
EP-1539041-A1 DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME Avantec Vascular Corporation (US) 2005-06-15 — — EP claimed
WO-2005051229-A2 DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME AVANTEC VASCULAR CORPORATION (US) 2005-06-09 — — WO claimed
US-20050125054-A1 Devices delivering therapeutic agents and methods regarding the same AVANTEC VASCULAR CORPORATION (US) 2005-06-09 — — US claimed
WO-2004010900-A1 DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME AVANTEC VASCULAR CORPORATION (US) 2004-02-05 — — WO claimed
US-6610483-B1 Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof PRINCETON UNIVERSITY 2003-08-26 — — US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
EP-1196626-A2 METHODS FOR IDENTIFYING INHIBITORS OF SIGNALING MOLECULES Princeton University (US) 2002-04-17 — — EP claimed
WO-2001007659-A2 METHODS FOR IDENTIFYING INHIBITORS OF SIGNALING MOLECULES PRINCETON UNIVERSITY (US) 2001-02-01 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230148436-A2 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF IFNG, IFNAR1, STING1 MAPT 4751/4885ALDH1A1 4334/4885LCK 383/4885
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB MAPT 3926/4885ALDH1A1 2722/4885LCK 4646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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