Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.36 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.36 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.36 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.36 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.36 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.36 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.36 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725528 | 0.92 | REN (0.40) | REN | |
| SCHEMBL14725254 | 0.91 | METAP2 (0.42) | TSHRALDH1A1ALOX15AAK1MAPT | |
| SCHEMBL14725272 | 0.91 | METAP2 (0.41) | TSHRALDH1A1ALOX15AAK1MAPT | |
| SCHEMBL14725494 | 0.83 | PSEN1 (0.42) | REN | |
| SCHEMBL14725258 | 0.82 | METAP2 (0.40) | AAK1PSMB5ANPEP | |
| SCHEMBL14725517 | 0.81 | AAK1 (0.44) | TSHRALDH1A1AAK1MAPTNPSR1 | |
| SCHEMBL14721685 | 0.79 | AAK1 (0.43) | TSHRAAK1 | |
| SCHEMBL14725450 | 0.79 | AAK1 (0.43) | TSHRAAK1 | |
| SCHEMBL14721210 | 0.76 | KDM4E (0.37) | TSHRALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL14725256 | 0.74 | METAP2 (0.39) | AAK1PSMB5ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |