Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725433 | 0.92 | TSHR (0.38) | REN | |
| SCHEMBL14725494 | 0.91 | PSEN1 (0.42) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14725517 | 0.88 | AAK1 (0.44) | REN | |
| SCHEMBL14725272 | 0.88 | METAP2 (0.41) | REN | |
| SCHEMBL14725254 | 0.87 | METAP2 (0.42) | — | |
| SCHEMBL14725437 | 0.81 | PSEN1 (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14721499 | 0.81 | PSEN1 (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14725543 | 0.79 | REN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14725258 | 0.78 | METAP2 (0.40) | — | |
| SCHEMBL14725511 | 0.78 | SRC (0.40) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |