SCHEMBL14725669

SCHEMBL14725669

Cn1cc2ccc3c(-c4ccc5oc6ccccc6c5c4)cc4cc5c(cc(-c6ccc7oc8ccccc8c7c6)c6ccc7cn(C)nc7c65)cc4c3c2n1

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 3/20 0.33
SIRT1 Q96EB6 3/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
MAPT P10636 3/20 0.33
NPC1 O15118 2/20 0.33
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
ALDH1A1 P00352 2/20 0.33
KMT2A Q03164 2/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CHEK2 O96017 1/20 0.32
MERTK Q12866 1/20 0.31
AHR P35869 2/20 0.30
ALOX5 P09917 1/20 0.30
ESR1 P03372 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14725675 0.81 GPR3 (0.31) MAPTALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL14725633 0.81 ADORA3 (0.36) MAPTKDM4EALDH1A1KMT2AHPGD
SCHEMBL14725668 0.76 ALOX5 (0.45) HSP90AA1HSP90AB1MAPTNPC1KDM4E
SCHEMBL14725643 0.75 ADORA3 (0.37) MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL21180552 0.74 TDP1 (0.44) HSP90AA1HSP90AB1MAPTNPC1KDM4E
SCHEMBL14725653 0.74 CYP11B1 (0.45) KDM4EALDH1A1HPGD
SCHEMBL14725637 0.73 CYP11B1 (0.39)
SCHEMBL17692091 0.73 TDP1 (0.49) HSP90AA1HSP90AB1MAPTNPC1KDM4E
SCHEMBL15461853 0.73 MAOA (0.38) HSP90AA1HSP90AB1MAPTNPC1KDM4E
SCHEMBL15945785 0.72 MAPT (0.50) HSP90AA1HSP90AB1MAPTNPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9255084-B2 Heterocyclic compound and organic light-emitting device containing the same SAMSUNG DISPLAY CO., LTD. (KR) 2016-02-09 US disclosed
US-20130048955-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING THE SAME SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2013-02-28 US disclosed
US-20130048955-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING THE SAME SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2013-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130048955-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING THE SAME TRPC1, TRPC4, TRPC6 SIRT2 1363/4885SIRT1 718/4885HSP90AA1 4468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.