Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.71 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068265 | 0.91 | MEN1 (0.85) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL15095092 | 0.86 | MEN1 (0.77) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL3574550 | 0.85 | MAPT (0.55) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL3574546 | 0.85 | MAPT (0.55) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL435677 | 0.84 | KMT2A (0.74) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL935186 | 0.84 | MEN1 (1.00) | MEN1KMT2AMAPTLMNANPSR1 | |
| Benzene SCHEMBL27988126 | 0.84 | MEN1 (1.00) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL4511467 | 0.83 | MAPT (0.50) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL4511463 | 0.83 | MAPT (0.50) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL4511458 | 0.83 | MAPT (0.50) | MEN1KMT2AMAPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815883-B2 | Compounds and methods for inhibiting serotonin synthesis | THE TRUSTEES OF COLUMBIA UNVIERSITY IN THE CITY OF NEW YORK (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815883-B2 | Compounds and methods for inhibiting serotonin synthesis | THE TRUSTEES OF COLUMBIA UNVIERSITY IN THE CITY OF NEW YORK (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130053343-A1 | COMPOUNDS AND METHODS FOR INHIBITING SEROTONIN SYNTHESIS | The Trustees of Columbia University in th City of (US) | 2013-02-28 | — | — | US | disclosed |
| US-20130053343-A1 | COMPOUNDS AND METHODS FOR INHIBITING SEROTONIN SYNTHESIS | The Trustees of Columbia University in th City of (US) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053343-A1 | COMPOUNDS AND METHODS FOR INHIBITING SEROTONIN SYNTHESIS | TPH1, TPH2, HTR1A | MEN1 290/4885KMT2A 589/4885MAPT 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.