Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12151902 | 0.91 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL12751903 | 0.85 | CYP3A4 (0.52) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL9914915 | 0.84 | CYP3A4 (0.55) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL1733111 | 0.83 | NOTUM (0.33) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL2629066 | 0.82 | CYP3A4 (0.75) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL1475113 | 0.82 | CYP3A4 (0.53) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL2629219 | 0.82 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| Hydrochloric Acid SCHEMBL1473309 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| Hydrochloric Acid SCHEMBL1473009 | 0.81 | CYP3A4 (0.52) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 | |
| SCHEMBL14867758 | 0.81 | CYP3A4 (0.64) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505752-B2 | Piperidine amide derivatives as HIV attachment inhibitors | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-11-29 | — | — | US | disclosed |
| US-9505752-B2 | Piperidine amide derivatives as HIV attachment inhibitors | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-11-29 | — | — | US | disclosed |
| EP-2895471-B1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2016-11-23 | — | — | EP | disclosed |
| EP-2646439-B1 | ALKYL AMIDES AS HIV ATTACHMENT INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-05-25 | — | — | EP | disclosed |
| EP-2646439-B1 | ALKYL AMIDES AS HIV ATTACHMENT INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-05-25 | — | — | EP | disclosed |
| US-9193725-B2 | Cyclic hydrazine derivatives as HIV attachment inhibitors | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193725-B2 | Cyclic hydrazine derivatives as HIV attachment inhibitors | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| US-20150105394-A1 | CYCLOLIC HYDRAZINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-04-16 | — | — | US | disclosed |
| US-20080139572-A1 | DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2008-06-12 | — | — | US | disclosed |
| US-7348337-B2 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348337-B2 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348337-B2 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| WO-2007127635-A2 | DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070249579-A1 | DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-25 | — | — | US | disclosed |
| EP-1513832-A2 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES | Bristol-Myers Squibb Company (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20040186292-A1 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2004-09-23 | — | — | US | disclosed |
| WO-2004043337-A2 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20040063744-A1 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063744-A1 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | IDO1, IDO2, INMT | CYP3A4 41/4885CYP2C9 520/4885CYP2D6 244/4885 |
| US-20150105394-A1 | CYCLOLIC HYDRAZINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | CD4, CCR5, VCAM1 | CYP3A4 43/4885CYP2C9 115/4885CYP2D6 99/4885 |
| US-20040186292-A1 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | IDO1, IDO2, INMT | CYP3A4 41/4885CYP2C9 520/4885CYP2D6 244/4885 |
| US-20080139572-A1 | DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS | EIF2AK2, DCK, MAVS | CYP3A4 1204/4885CYP2C9 3136/4885CYP2D6 1096/4885 |
| US-20070249579-A1 | DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS | EIF2AK2, DCK, MAVS | CYP3A4 1204/4885CYP2C9 3136/4885CYP2D6 1096/4885 |
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | CD4, HDAC5, ITGA5 | CYP3A4 1107/4885CYP2C9 2336/4885CYP2D6 3112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.