SCHEMBL14734397

SCHEMBL14734397

Cc1nc2cccc(F)c2nc1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.44
PARP1 P09874 1/20 0.41
GPR3 P46089 1/20 0.39
RAD52 P43351 1/20 0.38
PDE2A O00408 2/20 0.38
PDE10A Q9Y233 2/20 0.38
KDM4E B2RXH2 4/20 0.38
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
GAA P10253 3/20 0.38
HPGD P15428 3/20 0.38
MEN1 O00255 2/20 0.38
NPC1 O15118 2/20 0.38
LMNA P02545 2/20 0.38
RAB9A P51151 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPK1 P28482 1/20 0.38
MBNL1 Q9NR56 1/20 0.37
ACHE P22303 2/20 0.37
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30118358 0.88 PIM1 (0.42) MAPTPARP1GPR3RAD52PDE2A
SCHEMBL2131272 0.84 ACHE (0.41) MAPTPARP1GPR3RAD52PDE2A
SCHEMBL14764585 0.84 TDP1 (0.40) MAPTPARP1RAD52PDE2APDE10A
SCHEMBL21857858 0.84 PARP1 (0.40) MAPTPARP1RAD52PDE2APDE10A
SCHEMBL14734341 0.84 PIM1 (0.40) MAPTPARP1GPR3RAD52PDE2A
SCHEMBL27993149 0.80 PIM1 (0.44) GPR3PDE10AKDM4EALDH1A1MEN1
SCHEMBL14764528 0.80 MAPT (0.41) MAPTPARP1RAD52KDM4EALDH1A1
SCHEMBL2018164 0.80 PARP1 (0.37) MAPTPARP1RAD52PDE10AKDM4E
SCHEMBL14764490 0.80 ALDH1A1 (0.41) MAPTPARP1RAD52KDM4EALDH1A1
SCHEMBL14734402 0.79 RAD52 (0.40) PARP1RAD52PDE10AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104610178-B A kind of preparation method of the double fluorine benzheterocycle conjugative monomers of iodine atom substitution 华南理工大学 2018-01-05 CN disclosed
WO-2013027794-A1 NOVEL COMPOUND AND USE THEREOF AS PDE10 INHIBITOR 田辺三菱製薬株式会社 (JP) 2013-02-28 WO disclosed