Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 13/20 | 0.57 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740162 | 0.94 | ABCB1 (0.59) | ABCB1DHCR7KMT2AABCG2 | |
| SCHEMBL14740386 | 0.91 | ABCB1 (0.53) | ABCB1DHCR7ABCG2 | |
| SCHEMBL14739412 | 0.91 | DHCR7 (0.60) | ABCB1DHCR7ABCG2 | |
| SCHEMBL14740199 | 0.91 | ABCB1 (0.53) | ABCB1DHCR7KMT2AABCG2 | |
| SCHEMBL14739302 | 0.90 | DHCR7 (0.59) | ABCB1DHCR7ABCG2 | |
| SCHEMBL14740223 | 0.88 | DHCR7 (0.64) | ABCB1DHCR7 | |
| SCHEMBL21773921 | 0.87 | ABCB1 (0.56) | ABCB1DHCR7ABCG2 | |
| SCHEMBL14739133 | 0.86 | ABCB1 (0.51) | ABCB1DHCR7 | |
| SCHEMBL14739101 | 0.86 | ABCB1 (0.52) | ABCB1DHCR7 | |
| SCHEMBL14739369 | 0.85 | ABCB1 (0.45) | ABCB1DHCR7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589626-B1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | UNIV NAT TAIWAN (TW) | 2024-06-12 | — | — | EP | disclosed |
| US-20200071274-A1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | NATIONAL TAIWAN UNIVERSITY (TW) | 2020-03-05 | — | — | US | disclosed |
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | ABCB1 275/4885DHCR7 760/4885KMT2A 3232/4885 |
| US-20200071274-A1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | HTR7, GPR27, HTR5A | ABCB1 328/4885DHCR7 1398/4885KMT2A 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.