Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740295 | 0.86 | MAOA (0.67) | CHRNA7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL3051846 | 0.85 | CHRNA7 (0.54) | CHRNA7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL11241355 | 0.85 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL3057093 | 0.83 | HCRTR1 (0.54) | CHRNA7HCRTR1HCRTR2 | |
| SCHEMBL28742794 | 0.81 | DRD2 (0.56) | MAOAHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL7279548 | 0.80 | DRD3 (0.59) | — | |
| Hydrochloric Acid SCHEMBL7272028 | 0.80 | DRD3 (0.59) | — | |
| SCHEMBL11245540 | 0.78 | PDE4D (0.50) | CHRNA7HCRTR1HCRTR2 | |
| SCHEMBL14755329 | 0.77 | CHRNA7 (0.74) | CHRNA7 | |
| SCHEMBL14740349 | 0.77 | DRD2 (0.61) | MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | CHRNA7 2982/4885HTR2A 2413/4885HTR2C 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.