Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.61 |
| ▸ | DRD1 | P21728 | 5/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 5/20 | 0.60 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739491 | 0.82 | MAOA (0.86) | DRD2DRD1DRD3SIGMAR1MAOA | |
| SCHEMBL6369716 | 0.77 | MAOA (0.63) | DRD2DRD1DRD3SIGMAR1MAOA | |
| SCHEMBL11248586 | 0.77 | DRD2 (0.50) | DRD2DRD1DRD3SIGMAR1 | |
| SCHEMBL22782327 | 0.77 | MAOA (0.67) | DRD2DRD1DRD3SIGMAR1MAOA | |
| SCHEMBL10658249 | 0.77 | MAOA (0.57) | DRD2DRD1DRD3SIGMAR1MAOA | |
| SCHEMBL14740318 | 0.77 | CHRNA7 (0.58) | MAOA | |
| SCHEMBL8034415 | 0.76 | MAOA (0.97) | DRD2DRD1DRD3MAOADRD5 | |
| SCHEMBL3050890 | 0.76 | DRD1 (0.64) | DRD2DRD1DRD3SIGMAR1MAOA | |
| Hydrochloric Acid SCHEMBL10662154 | 0.76 | MAOA (0.59) | DRD2DRD1DRD3SIGMAR1MAOA | |
| Hydrochloric Acid SCHEMBL11141916 | 0.76 | DRD3 (0.67) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | DRD2 3681/4885DRD1 4662/4885DRD3 4205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.