Iopentol

Iopentol

SCHEMBL14740647

CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I.COCC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.84
HIF1A Q16665 1/20 0.84
LMNA P02545 2/20 0.80
EGFR P00533 1/20 0.32
SRC P12931 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iopentol SCHEMBL8845316 0.99 LMNA (0.82) CYP2C19HIF1ALMNAEGFRSRC
Iopentol SCHEMBL24471 0.99 LMNA (0.82) CYP2C19HIF1ALMNAEGFRSRC
Iodixanol SCHEMBL28086309 0.98 LMNA (0.84) CYP2C19HIF1ALMNAEGFRSRC
SCHEMBL10058205 0.95 LMNA (0.76) CYP2C19HIF1ALMNAEGFRSRC
SCHEMBL9564078 0.95 LMNA (0.76) CYP2C19HIF1ALMNAEGFRSRC
Iohexol SCHEMBL26501 0.92 CYP2C19 (1.00) CYP2C19HIF1ALMNAEGFRSRC
Iohexol SCHEMBL37920 0.92 CYP2C19 (1.00) CYP2C19HIF1ALMNAEGFRSRC
Iohexol SCHEMBL31722694 0.92 CYP2C19 (1.00) CYP2C19HIF1ALMNAEGFRSRC
Iohexol SCHEMBL8844889 0.92 CYP2C19 (1.00) CYP2C19HIF1ALMNAEGFRSRC
SCHEMBL682143 0.91 LMNA (0.80) CYP2C19HIF1ALMNAEGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2750711-A2 REMOTE ASSEMBLY OF TARGETED NANOPARTICLES USING H-PHOSPHONATE-ENE/-YNE HYDROPHOSPHONYLATION REACTIONS Mallinckrodt LLC (US) 2014-07-09 EP disclosed
WO-2013033450-A2 REMOTE ASSEMBLY OF TARGETED NANOPARTICLES USING H-PHOSPHONATE-ENE/-YNE HYDROPHOSPHONYLATION REACTIONS MALLINCKRODT LLC (US) 2013-03-07 WO disclosed