Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743911 | 0.91 | ALDH1A1 (0.39) | TDP1KMT2ATHRBPOLBCHRM4 | |
| SCHEMBL14743576 | 0.90 | KMT2A (0.48) | TDP1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL14743424 | 0.90 | TDP1 (0.52) | TDP1KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL14743033 | 0.87 | TDP1 (0.41) | TDP1KMT2ATHRBPOLBMEN1 | |
| SCHEMBL14743819 | 0.84 | LMNA (0.34) | TDP1KMT2ATHRBCHRM4ALDH1A1 | |
| SCHEMBL14742993 | 0.84 | GAA (0.34) | TDP1KMT2ATHRBMEN1ALDH1A1 | |
| SCHEMBL14743626 | 0.83 | GAA (0.48) | KMT2APOLBMEN1ALDH1A1MAPT | |
| SCHEMBL14743642 | 0.82 | HPGDS (0.37) | TDP1CHRM4ALDH1A1OPRM1OPRL1 | |
| SCHEMBL14743068 | 0.81 | PSMD14 (0.38) | KMT2APOLBCHRM4MEN1ALDH1A1 | |
| SCHEMBL14743411 | 0.81 | TDP1 (0.50) | TDP1KMT2APOLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | claimed |
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |