Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | SHBG | P04278 | 1/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11517499 | 0.90 | LMNA (0.60) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL312243 | 0.81 | ESR1 (1.00) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL30503014 | 0.81 | ESR1 (1.00) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL8663113 | 0.81 | NPC1 (0.51) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL7253586 | 0.79 | HSP90AB1 (0.69) | ESR1SHBGESR2LMNAHTT | |
| SCHEMBL27735150 | 0.79 | HSP90AB1 (0.53) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL3820741 | 0.79 | ESR1 (0.81) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL13640734 | 0.79 | ESR1 (0.75) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL38652384 | 0.79 | ESR1 (0.81) | ESR1SHBGESR2LMNANPC1 | |
| SCHEMBL22887515 | 0.79 | MRGPRX4 (0.50) | ESR1SHBGESR2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389548-B2 | Administering an estrogen receptor for treatment of osteoporosis, breast cancer, hypercholesteremia, hyperlipidemia or artheriosclerosis by administering estrogen modulators | ENDORECHERCHE, INC. (CA) | 2013-03-05 | — | — | US | disclosed |
| US-8389548-B2 | Administering an estrogen receptor for treatment of osteoporosis, breast cancer, hypercholesteremia, hyperlipidemia or artheriosclerosis by administering estrogen modulators | ENDORECHERCHE, INC. (CA) | 2013-03-05 | — | — | US | disclosed |