Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747497 | 0.91 | TAS1R3 (0.46) | EPHX2KDM1AMAOAMAOBMEN1 | |
| SCHEMBL14747464 | 0.81 | KDM1A (0.46) | EPHX2KDM1AMAOAMAOBRAB9A | |
| SCHEMBL12976713 | 0.73 | ALDH1A1 (0.46) | CYP1A2CYP2D6CYP2C19KDM1AMAOA | |
| SCHEMBL14747496 | 0.73 | SLC6A2 (0.43) | EPHX2KDM1AMAOAMAOBKMT2A | |
| SCHEMBL15099843 | 0.71 | KDM1A (0.68) | KDM1AMAOAMAOBRAB9AHDAC6 | |
| SCHEMBL3266423 | 0.71 | KDM1A (0.68) | KDM1AMAOAMAOBRAB9AHDAC6 | |
| SCHEMBL10273072 | 0.71 | KDM1A (0.68) | KDM1AMAOAMAOBRAB9AHDAC6 | |
| SCHEMBL2773583 | 0.71 | SMN1; SMN2 (0.49) | CYP1A2EPHX2KDM1AMAOAMAOB | |
| SCHEMBL2773586 | 0.71 | SMN1; SMN2 (0.49) | CYP1A2EPHX2KDM1AMAOAMAOB | |
| SCHEMBL14747475 | 0.69 | FFAR1 (0.52) | MAPTTSHRRAB9APLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389580-B2 | Arylcyclopropylamines and methods of use | DUKE UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |