Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.43 |
| ▸ | FOS | P01100 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911890 | 0.94 | SIGMAR1 (0.45) | SIGMAR1FOSTTRJUNNR3C1 | |
| SCHEMBL12856097 | 0.90 | HTR1A (0.44) | SIGMAR1CYP3A4 | |
| SCHEMBL12961274 | 0.88 | SIGMAR1 (0.43) | SIGMAR1FOSTTRJUNNR3C1 | |
| SCHEMBL14747869 | 0.84 | HTR1A (0.41) | SIGMAR1CYP3A4 | |
| SCHEMBL14747860 | 0.81 | TAS1R3 (0.47) | SIGMAR1FOSTTRJUNNR3C1 | |
| SCHEMBL22605163 | 0.78 | TDP1 (0.38) | SIGMAR1CYP3A4TAS1R3TAS1R1 | |
| SCHEMBL16151510 | 0.76 | FOS (0.66) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL6126233 | 0.76 | FOS (0.51) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL14747858 | 0.76 | TAS1R3 (0.43) | SIGMAR1ALOX15ALOX12TAS1R3TAS1R1 | |
| SCHEMBL26831762 | 0.75 | SIGMAR1 (0.50) | SIGMAR1LDHAALOX15ALOX12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |