Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.76 |
| ▸ | MEN1 | O00255 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.76 |
| ▸ | POLB | P06746 | 8/20 | 0.76 |
| ▸ | USP2 | O75604 | 2/20 | 0.76 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.76 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.76 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | CDC7 | O00311 | 1/20 | 0.66 |
| ▸ | PLK4 | O00444 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14476502 | 0.90 | MAPT (0.86) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL5594542 | 0.86 | MAPT (1.00) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL12351294 | 0.86 | MAPT (0.83) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL10476363 | 0.82 | MEN1 (1.00) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL17799202 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL17799204 | 0.82 | MAPT (0.76) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL10476364 | 0.78 | MAPT (0.82) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL10476385 | 0.78 | KMT2A (0.73) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL10476383 | 0.78 | KMT2A (0.73) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL27983596 | 0.78 | MAPT (0.78) | MAPTMEN1KMT2APOLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180100166-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2018-04-12 | — | — | US | disclosed |
| US-20180085383-A1 | SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2018-03-29 | — | — | US | disclosed |
| US-9845482-B2 | Compositions and methods for enhancing bioenergetic status in female germ cells | THE GENERAL HOSPITAL CORPORATION (US) | 2017-12-19 | — | — | US | disclosed |
| US-20160024527-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-01-28 | — | — | US | disclosed |
| US-20140221319-A1 | Small Molecule CD38 Inhibitors and Methods of Using Same | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130059384-A1 | COMPOSITIONS AND METHODS FOR ENHANCING BIOENERGETIC STATUS IN FEMALE GERM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221319-A1 | Small Molecule CD38 Inhibitors and Methods of Using Same | CD38, CD22, CD2 | MAPT 3783/4885MEN1 2938/4885KMT2A 1089/4885 |
| US-20180100166-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PCK2, GSR, TFAM | MAPT 4110/4885MEN1 4369/4885KMT2A 2889/4885 |
| US-20130059384-A1 | COMPOSITIONS AND METHODS FOR ENHANCING BIOENERGETIC STATUS IN FEMALE GERM CELLS | PCK2, GSR, TFAM | MAPT 4110/4885MEN1 4369/4885KMT2A 2889/4885 |
| US-20160024527-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PCK2, GSR, TFAM | MAPT 4110/4885MEN1 4369/4885KMT2A 2889/4885 |
| US-20180085383-A1 | SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME | CD38, BCL6B, DNASE1L3 | MAPT 3326/4885MEN1 3469/4885KMT2A 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.