Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 9/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 9/20 | 0.58 |
| ▸ | PDK3 | Q15120 | 9/20 | 0.58 |
| ▸ | PDK4 | Q16654 | 9/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871849 | 0.90 | HRH3 (0.50) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL26071914 | 0.86 | CYP11B1 (0.47) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL26071793 | 0.84 | PDK1 (0.54) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL14756207 | 0.84 | PDK1 (0.54) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL14756232 | 0.82 | PDK1 (0.47) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL14756175 | 0.81 | BRD4 (0.56) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL14756761 | 0.81 | PDK1 (0.45) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL30366353 | 0.81 | PDK1 (0.48) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL26072484 | 0.81 | PDK1 (0.48) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL26071772 | 0.81 | ALDH1A1 (0.45) | PDK1PDK2PDK3PDK4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |