Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.80 |
| ▸ | RAB9A | P51151 | 9/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.60 |
| ▸ | SCD | O00767 | 2/20 | 0.54 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1475653 | 0.89 | NPC1 (1.00) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1474855 | 0.87 | NPC1 (1.00) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1474512 | 0.85 | ALDH1A1 (0.86) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1474191 | 0.83 | NPC1 (0.72) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL15190211 | 0.82 | ALDH1A1 (0.57) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1474842 | 0.80 | ALDH1A1 (0.81) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1475419 | 0.80 | ALDH1A1 (0.64) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1477503 | 0.79 | NPC1 (0.69) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1475066 | 0.79 | NPC1 (0.69) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1474317 | 0.79 | RAB9A (0.69) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971600-B1 | ISOXAZOLE DERIVATIVES AND USE THEREOF | SK BIOPHARMACEUTICALS CO LTD (KR) | 2013-08-21 | — | — | EP | disclosed |
| US-7915297-B2 | Isoxazole derivatives and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-03-29 | — | — | US | disclosed |
| US-7915297-B2 | Isoxazole derivatives and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-03-29 | — | — | US | disclosed |
| US-7915297-B2 | Isoxazole derivatives and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-03-29 | — | — | US | disclosed |
| US-20090131336-A1 | Isoxazole Derivatives and Use Thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-05-21 | — | — | US | disclosed |
| US-20090131336-A1 | Isoxazole Derivatives and Use Thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-05-21 | — | — | US | disclosed |
| WO-2007078113-A1 | ISOXAZOLE DERIVATIVES AND USE THEREOF | SK HOLDINGS CO., LTD. (KR) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131336-A1 | Isoxazole Derivatives and Use Thereof | WNT3A, WNT1, WNT3 | NPC1 2242/4885ALDH1A1 706/4885RAB9A 2013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.