Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MYLK | Q15746 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199441 | 0.93 | MEN1 (0.44) | ALDH1A1HTTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3988068 | 0.88 | MGLL (0.41) | ALDH1A1HTTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6194063 | 0.84 | CACNA1F (0.41) | MEN1KMT2ACACNA1FCACNA1DCACNA1S | |
| SCHEMBL6195392 | 0.83 | CACNA1F (0.40) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL6641617 | 0.82 | CACNA1F (0.41) | ALDH1A1HTTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4294571 | 0.80 | MGLL (0.42) | MEN1KMT2AMAPTCACNA1FCACNA1D | |
| SCHEMBL6247829 | 0.80 | CACNA1F (0.36) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL6194820 | 0.77 | MAPT (0.47) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL6644031 | 0.75 | MYLK (0.39) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL6197215 | 0.75 | ADRA1A (0.36) | MEN1KMT2ACACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766366-B1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHBITORS | CHIESI FARMA SPA (IT) | 2016-11-09 | — | — | EP | disclosed |
| EP-2766366-B1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHBITORS | CHIESI FARMA SPA (IT) | 2016-11-09 | — | — | EP | disclosed |
| US-9023855-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9023855-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9023855-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-20140179714-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-26 | — | — | US | disclosed |
| US-20140179714-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-26 | — | — | US | disclosed |
| US-20140179714-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-26 | — | — | US | disclosed |
| WO-2013037809-A1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-21 | — | — | WO | disclosed |
| US-20130065913-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-14 | — | — | US | disclosed |
| US-20130065913-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-14 | — | — | US | disclosed |
| US-20130065913-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065913-A1 | NOVEL COMPOUNDS | SERPINB1, ELANE, MPO | ALDH1A1 1415/4885HTT 4664/4885CYP3A4 1766/4885 |
| US-20140179714-A1 | NOVEL COMPOUNDS | SERPINB1, ELANE, MPO | ALDH1A1 1414/4885HTT 4664/4885CYP3A4 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.